Purpose of Review: Circadian rhythms, including 24-h activity rhythms, change with age. Disturbances in these 24-h activity rhythms at older age have also been implied in various diseases. This review evaluates recent findings on 24-h activity rhythms and disease in older adults.
Recent Findings: Growing evidence supports that 24-h activity rhythm disturbances at older age are related to the presence and/or progression of disease. Longitudinal and genetic work even suggests a potential causal contribution of disturbed 24-h activity rhythms to disease development. Interventional studies targeting circadian and 24-h activity rhythms demonstrate that 24-h rhythmicity can be improved, but the effect of improving 24-h rhythmicity on disease risk or progression remains to be shown.
Summary: Increasing evidence suggests that 24-h activity rhythms are involved in age-related diseases. Further studies are needed to assess causality, underlying mechanisms, and the effects of treating disturbed 24-h activity rhythms on age-related disease.

Accelerometry, Actigraphy, Age-related disease, Aging, Circadian rhythm, Rest-activity rhythm
dx.doi.org/10.1007/s40675-020-00170-2, hdl.handle.net/1765/126566
Current Sleep Medicine Reports
Department of Epidemiology

de Feijter, M, Lysen, T.S, & Luik, A.I. (2020). 24-h Activity Rhythms and Health in Older Adults. Current Sleep Medicine Reports (Vol. 6, pp. 76–83). doi:10.1007/s40675-020-00170-2