2020-06-03
Cerebellar Supervision of Action: Small brother is watching you
Publication
Publication
Cerebellair toezicht op actie: Kleine broer houdt je in de gaten
Synaptic plasticity has been historically considered the primary neural correlate of
learning and memory.
Initially, depression at the parallel fiber to Purkinje cell synapse was considered the
sole cellular mechanism underlying cerebellar motor learning. In line with other findings
of the past decade, this thesis shows the importance of other forms of cerebellar
plasticity, in particular that of Purkinje cell potentiation. More specifically, we show the
relevance of this form of postsynaptic plasticity during adjustments of whisker protraction,
licking and respiration. Based upon these findings, I suggest that intrinsic excitability
and potentiation of the parallel fiber to Purkinje cell synapse result in increased
simple spike activity, which in turn leads to faster sensorimotor integration. These results
imply that deficits in such neuronal mechanisms can contribute to impairments in the
acquisition and execution of faster reflexes in cerebellar patients.
Additional Metadata | |
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C.I. de Zeeuw (Chris) , L.W.J. Bosman (Laurens) | |
Erasmus University Rotterdam | |
hdl.handle.net/1765/126587 | |
Romano, V. (2020, June 3). Cerebellar Supervision of Action: Small brother is watching you. Retrieved from http://hdl.handle.net/1765/126587 |
Additional Files | |
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Cover-Romano.PNG Cover Image , 492kb | |
propositionsromano.pdf , 69kb | |
126587_Chapter_1-Introduction.pdf Final Version , 2mb | |
126587_Chapter_2-Cerebellar_Potentiation_and_Learning_a_W.pdf Final Version , 7mb | |
126587_Chapter_3-Potentiation_of_cerebellar_Purkinje_cell.pdf Final Version , 19mb | |
126587_Chapter_4-Quasiperiodic_rhythms_of_the_inferior_ol.pdf Final Version , 19mb | |
126587_Chapter_5-Functional_convergence_of_autonomic_and.pdf Final Version , 19mb | |
126587_Chapter_6-Cerebellar_Purkinje_cells_can_differenti.pdf Final Version , 20mb | |
126587_Chapter_7-General_discussion.pdf Final Version , 802kb |