Background: Exposure to bisphenols and phthalates might influence bone health. We hypothesized that exposure to bisphenols and phthalates during fetal life has persistent effects on bone development. Objectives: To analyze the associations of fetal exposure to bisphenols and phthalates with bone health in school-aged children. Methods: Among 1,362 mother-child pairs participating in a population-based cohort study, we measured maternal urinary concentrations of bisphenols and phthalates at first, second and third trimester with high performance liquid chromatography electrospray ionization-tandem mass spectrometry. Total body bone mineral density (BMD) and bone area (BA) were measured using dual-energy X-ray absorptiometry (DXA) at 6 and 10 years, and were both used to calculate bone mineral content (BMC) and area-adjusted BMC (aBMC, a measure of volumetric BMD). Results: Maternal bisphenol concentrations were not associated with childhood bone measures at 6 years. After adjustment for covariates and multiple testing correction, an interquartile range increase in maternal first trimester bisphenol S (BPS) concentrations was associated with lower BMD and aBMC at 10 years (−6.08 (95% confidence interval (CI), −9.97 to −2.19) mg/cm2 and -0.12 (95% CI, −0.20 to −0.04) g). Maternal third trimester low molecular weight (LMW) phthalate concentrations were associated with higher aBMC at 6 years whereas, maternal third trimester di-n-octylphthalate (DNOP) concentrations were associated with lower aBMC at 10 years. However, these associations did not remain statistically significant after multiple testing correction. Discussion: Maternal first trimester BPS concentrations are associated with lower BMD and aBMC in school-aged children. These findings should be considered as hypothesis generating and need further replication and exploration of potential underlying mechanisms.

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Keywords Bisphenol, Bone mineral content, Bone mineral density, Endocrine disruptor, Phthalate
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Journal Environmental Research
van Zwol - Janssens, C. (Charissa), Trasande, L. (Leonardo), Asimakopoulos, A.G. (Alexandros G.), Martinez-Moral, M.-P. (Maria-Pilar), Kannan, K. (Kurunthachalam), Philips, E.M. (Elise M.), … Santos, S. (Susana). (2020). Fetal exposure to bisphenols and phthalates and childhood bone mass: a population-based prospective cohort study. Environmental Research, 186. doi:10.1016/j.envres.2020.109602