The majority of familial noncompaction cardiomyopathy (NCCM) is explained by pathogenic variants in the same sarcomeric genes that are associated with hypertrophic (HCM) and dilated (DCM) cardiomyopathy. Pathogenic variants in the filamin C gene (FLNC) have been linked to HCM and DCM. We expand the spectrum of FLNC related cardiomyopathies by presenting two families with likely pathogenic FLNC variants showing familial segregation of NCCM and concurrent coarctation of the aorta and/or mitral valve abnormalities.

Additional Metadata
Persistent URL dx.doi.org/10.4081/cardiogenetics.2019.8181, hdl.handle.net/1765/127154
Journal Cardiogenetics
Citation
van Waning, J, Hoedemaekers, Y.M., te Rijdt, W.P., Jpma, A.I., Heijsman, D, Caliskan, K.C, … van der Zwaag, P.A. (2019). FLNC missense variants in familial noncompaction cardiomyopathy. Cardiogenetics, 9(1), 9–13. doi:10.4081/cardiogenetics.2019.8181