An increasingly number of original studies on safety and efficacy of HIFU as salvage treatment in local radio-recurrent prostate cancer has been published. This review of systematic reviews (SRs) gives insight in the current practice and scientific background of salvage HIFU in radio-recurrent prostate cancer. The most recent and also largest SR review included showed no difference in survival between HIFU and salvage radical prostatectomy. However, the morbidity after salvage HIFU was lower than after salvage radical prostatectomy. Pending future studies with higher evidence salvage HIFU might be seen as promising alternative treatment in patients with local radiorecurrent prostate cancer. Certainly for the patient in whom age and patient’s wishes and disease stage point to refraining from more aggressive therapy. The currently available evidence provides sufficient grounds to offer HIFU as salvage treatment rather than no treatment or androgen deprivation therapy.

HIFU, radiorecurrent, systematic review,
Tijdschrift voor Urologie
Erasmus MC: University Medical Center Rotterdam

Lemmens, V.E.P.P, & van Aubel, O.G.J.M. (Olav G. J. M.). (2020). High-intensity focused ultrasound (HIFU) as salvage treatment in radio-recurrent prostate cancer: current scientific background and practice. A review of systematic reviews High-intensity focussed ultrasound (HIFU) als salvagebehandeling van recidiverend prostaatcarcinoom: stand van zaken wetenschap en praktijk. Een review van systematische reviews. Tijdschrift voor Urologie. doi:10.1007/s13629-020-00291-x