Purpose: Real-world studies to describe the use of first, second and third line therapies for the management and symptomatic treatment of dementia are lacking. This retrospective cohort study describes the first-, second- and third-line therapies used for the management and symptomatic treatment of dementia, and in particular Alzheimer’s Disease. Methods: Medical records of patients with newly diagnosed dementia between 1997 and 2017 were collected using four databases from the UK, Denmark, Italy and the Netherlands. Results: We identified 191,933 newly diagnosed dementia patients in the four databases between 1997 and 2017 with 39,836 (IPCI (NL): 3281, HSD (IT): 1601, AUH (DK): 4474, THIN (UK): 30,480) fulfilling the inclusion criteria, and of these, 21,131 had received a specific diagnosis of Alzheimer’s disease. The most common first line therapy initiated within a year (± 365 days) of diagnosis were Acetylcholinesterase inhibitors, namely rivastigmine in IPCI, donepezil in HSD and the THIN and the N-methyl-d-aspartate blocker memantine in AUH. Conclusion: We provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer’s Disease patients from across Europe.

Alzheimer’s disease, Dementia, Epidemiology, Real-world data
dx.doi.org/10.1007/s00127-020-01872-2, hdl.handle.net/1765/127737
Social Psychiatry and Psychiatric Epidemiology: the international journal for research in social and genetic epidemiology and mental health services
Erasmus MC: University Medical Center Rotterdam

James, G. (Glen), Collin, E. (Estelle), Lawrance, M. (Marcus), Mueller, A. (Achim), Podhorna, J. (Jana), Zaremba-Pechmann, L. (Liliana), … Gordon, M.F. (Mark Forrest). (2020). Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe. Social Psychiatry and Psychiatric Epidemiology: the international journal for research in social and genetic epidemiology and mental health services. doi:10.1007/s00127-020-01872-2