Anticoagulant properties, clinical efficacy and safety of efegatran, a direct thrombin inhibitor, in patients with unstable angina.
AIMS: Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS: Four hundred and thirty-two patients with unstable angina were enrolled. Five dose levels of efegatran were studied sequentially, ranging from 0.105 mg. kg(-1). h(-1)to 1.2 mg. kg(-1). h(-1)over 48 h. Safety was assessed clinically, with reference to bleeding and by measuring clinical laboratory parameters. Efficacy was assessed by the number of patients experiencing any episode of recurrent ischaemia as measured by computer-assisted continuous ECG ischaemia monitoring. Clinical end-points were: episodes of recurrent angina, myocardial infarction, coronary intervention (PTCA or CABG), and death. RESULTS: Efegatran demonstrated dose dependent ex-vivo anticoagulant activity with the highest dose level of 1.2 mg. kg(-1). h(-1)resulting in steady state mean activated partial thromboplastin time values of approximately three times baseline. Thrombin time was also increased. Neither of the efegatran doses studied were able to suppress myocardial ischaemia during continuous ECG ischaemia monitoring to a greater extent than that seen with heparin. There were no statistically significant differences in clinical outcome or major bleeding between the efegatran and heparin groups. Minor bleeding and thrombophlebitis occurred more frequently in the efegatran treated patients. CONCLUSION: Administration of efegatran sulphate at levels of at least 0.63 mg. kg(-1). h(-1)provided an anti-thrombotic effect which is at least comparable to an activated partial thromboplastin time adjusted heparin infusion. There was no excess of major bleeding. The level of thrombin inhibition by efegatran, as measured by activated partial thromboplastin time, appeared to be more stable than with heparin. Thus, like other thrombin inhibitors, efegatran sulphate is easier to administer than heparin. However, no clinical benefits of efegatran over heparin were apparent.
|Keywords||Adult, Aged, Angina, Unstable/*drug therapy, Anticoagulants/administration & dosage/*therapeutic use, Antithrombins/administration & dosage/*therapeutic use, Dose-Response Relationship, Drug, ECG ischaemia monitoring, Electrocardiography, Female, Heparin/therapeutic use, Humans, Male, Middle Aged, Monitoring, Ambulatory/methods, Oligopeptides/administration & dosage/*therapeutic use, Partial Thromboplastin Time, Research Support, Non-U.S. Gov't, Single-Blind Method, Treatment Outcome, anti-thrombin, efegatran, unstable angina|
|Persistent URL||dx.doi.org/10.1053/euhj.1999.1477, hdl.handle.net/1765/12808|
|Journal||European Heart Journal|
Klootwijk, P, Lenderink, T, Meij, S, Melkert, R, Umans, V.A.W.M, Stibbe, J, … Boersma, H. (1999). Anticoagulant properties, clinical efficacy and safety of efegatran, a direct thrombin inhibitor, in patients with unstable angina. European Heart Journal, 20(15), 1101–1111. doi:10.1053/euhj.1999.1477