Potential Determinants in Malignancy Growth, Angiogenesis and Metastasis

The tumorigenesis and progression of malignancy is intricate with composition of various genetic alterations and pathways regulating cell growth and death, differentiation, migration, invasion and interaction with tumor microenvironment.

The objective of this thesis is to link phenotypic features with genetic modulators in melanoma and colorectal carcinoma to find potential intrinsic drivers of tumor progression, which may serve as a target or inspire further development of therapeutic strategies in melanoma and colorectal carcinoma.