2020-07-06
An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment
Publication
Publication
Nature Communications , Volume 11 - Issue 1
The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the selected assays there is a wide diversity in assay performance in different scenarios and when correlated to virus neutralizing antibodies. The Wantai ELISA detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, has the best overall characteristics to detect functional antibodies in different stages and severity of disease, including the potential to set a cut-off indicating the presence of protective antibodies. The large variety of available serological assays requires proper assay validation before deciding on deployment of assays for specific applications.
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| doi.org/10.1038/s41467-020-17317-y, hdl.handle.net/1765/128638 | |
| Nature Communications | |
| Organisation | Department of Virology |
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Geurts van Kessel, C., Okba, N., Igloi, Z. (Zsofia), Bogers, S. (Susanne), Embregts, C.W.E. (Carmen W. E.), Laksono, B., … Koopmans, M., D.V.M. (2020). An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment. Nature Communications, 11(1). doi:10.1038/s41467-020-17317-y |
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