HIV-associated and idiopathic-acquired haemophilia a: A single-centre case series from Cape Town, South Africa
The Netherlands Journal of Medicine , Volume 78 - Issue 4 p. 196- 201
Acquired haemophilia A is a rare coagulation disorder, which can lead to life-threatening haemorrhages if not identified and treated promptly. It is characterised by the presence of autoantibodies (inhibitors) to factor VIII. Acquired haemophilia A associated with HIV is a rare but well described phenomenon with limited directions to its management. We comparatively describe four patients – two with HIV and two without-that presented with unusual bleeding episodes with a prolonged activated partial thromboplastin time secondary to factor VIII inhibitors. An empiric observation is that the patients with acquired haemophilia A associated with HIV had higher antibody titres at presentation, that required more prolonged immunosuppressive therapy to induce remission.
|Acquired haemophilia, HIV|
|The Netherlands Journal of Medicine|
|Organisation||Erasmus University Rotterdam|
Shein, R. (R.), du Toit, J. (J.), Goeijenbier, M, du Toit, C. (C.), & Verburgh, E. (Estelle). (2020). HIV-associated and idiopathic-acquired haemophilia a: A single-centre case series from Cape Town, South Africa. The Netherlands Journal of Medicine, 78(4), 196–201. Retrieved from http://hdl.handle.net/1765/128684