Acquired haemophilia A is a rare coagulation disorder, which can lead to life-threatening haemorrhages if not identified and treated promptly. It is characterised by the presence of autoantibodies (inhibitors) to factor VIII. Acquired haemophilia A associated with HIV is a rare but well described phenomenon with limited directions to its management. We comparatively describe four patients – two with HIV and two without-that presented with unusual bleeding episodes with a prolonged activated partial thromboplastin time secondary to factor VIII inhibitors. An empiric observation is that the patients with acquired haemophilia A associated with HIV had higher antibody titres at presentation, that required more prolonged immunosuppressive therapy to induce remission.

The Netherlands Journal of Medicine
Erasmus University Rotterdam

Shein, R. (R.), du Toit, J. (J.), Goeijenbier, M, du Toit, C. (C.), & Verburgh, E. (Estelle). (2020). HIV-associated and idiopathic-acquired haemophilia a: A single-centre case series from Cape Town, South Africa. The Netherlands Journal of Medicine, 78(4), 196–201. Retrieved from