Ileocolic intussusception is the invagination of ileum into the colon. In a subset of patients, the disease is caused by mesenteric lymphadenopathy in response to (viral) infection. We present a case of an ileocolic intussusception necessitating surgery in a 7-month-old immunocompetent infant with concurrent primary wild-type varicella-zoster virus (VZV) infection, in whom chickenpox rash developed 2 days after surgery. Detailed in situ analyses of resected intestine for specific cell type markers and VZV RNA demonstrated VZV-infected lymphocytes and neurons in the gut wall and in ganglion cells of the myenteric plexus.

Additional Metadata
Keywords chickenpox, enteric nervous system, ganglion, Intussusception, lymphocyte, varicella-zoster virus
Persistent URL dx.doi.org/10.1093/infdis/jiaa148, hdl.handle.net/1765/128688
Journal The Journal of Infectious Diseases
Citation
Windster, J.D. (Jonathan D.), Ouwendijk, W.J.D, Sloots, C.E.J, Verjans, G.M.G.M, & Verdijk, R.M. (2020). Ileocolic Intussusception as the Presenting Symptom of Primary Enteric Varicella-Zoster Virus Infection in a 7-Month-Old Infant. The Journal of Infectious Diseases, 222(2), 305–308. doi:10.1093/infdis/jiaa148