Ileocolic intussusception is the invagination of ileum into the colon. In a subset of patients, the disease is caused by mesenteric lymphadenopathy in response to (viral) infection. We present a case of an ileocolic intussusception necessitating surgery in a 7-month-old immunocompetent infant with concurrent primary wild-type varicella-zoster virus (VZV) infection, in whom chickenpox rash developed 2 days after surgery. Detailed in situ analyses of resected intestine for specific cell type markers and VZV RNA demonstrated VZV-infected lymphocytes and neurons in the gut wall and in ganglion cells of the myenteric plexus.

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The Journal of Infectious Diseases

Windster, J.D. (Jonathan D.), Ouwendijk, W.J.D, Sloots, C.E.J, Verjans, G.M.G.M, & Verdijk, R.M. (2020). Ileocolic Intussusception as the Presenting Symptom of Primary Enteric Varicella-Zoster Virus Infection in a 7-Month-Old Infant. The Journal of Infectious Diseases, 222(2), 305–308. doi:10.1093/infdis/jiaa148