Chronic liver diseases (CLDs) have been documented to exacerbate clinical outcomes of acute hepatitis E (AHE). This study aimed to uncover the role of etiology and status of CLD in the adverse outcomes of AHE. We found that superinfection with hepatitis E virus (HEV) in patients with cirrhotic CLD can cause a worsen outcome, leading to exacerbation of AHE, compared with HEV-infected patients without CLD or with noncirrhotic CLD. Additional analysis revealed that the etiology of CLD is not associated with outcomes of AHE patients. These finding suggests that the overall liver status plays a predominant role in determining the outcomes of AHE.

hepatitis E, background liver diseases, cirrhotic liver diseases, etiology.
dx.doi.org/10.1093/ofid/ofaa107, hdl.handle.net/1765/128708
Open Forum Infectious Diseases
Department of Gastroenterology & Hepatology

Wang, Y, Liu, H.Y., Jiang, Y.Y., Pan, Q, & Zhao, J.M. (2020). Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology. Open Forum Infectious Diseases, 7(4). doi:10.1093/ofid/ofaa107