Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables
United European Gastroenterology Journal
Background: Individuals with a very high lifetime risk of developing pancreatic ductal adenocarcinoma; for example, hereditary pancreatitis and main-duct or mixed-type intraductal papillary mucinous neoplasm, may wish to discuss prophylactic total pancreatectomy but strategies to do so are lacking. Objective: To develop a shared decision-making programme for prophylactic total pancreatectomy using decision tables. Methods: Focus group meetings with patients were used to identify relevant questions. Systematic reviews were performed to answer these questions. Results: The first tables included hereditary pancreatitis and main-duct or mixed-type intraductal papillary mucinous neoplasm. No studies focused on prophylactic total pancreatectomy in these groups. In 52 studies (3570 patients), major morbidity after total pancreatectomy was 25% and 30-day mortality was 6%. After minimally invasive total pancreatectomy (seven studies, 35 patients) this was, respectively, 13% and 0%. Exocrine insufficiency-related symptoms occurred in 33%. Quality of life after total pancreatectomy was slightly lower compared with the general population. Conclusion: The decision tables can be helpful for discussing prophylactic total pancreatectomy with individuals at high risk of pancreatic ductal adenocarcinoma.
|cancer risk, diabetes mellitus, hereditary pancreatitis, intraductal papillary mucinous neoplasm, mutation, Pancreatic ductal adenocarcinoma, prophylactic total pancreatectomy|
|United European Gastroenterology Journal|
|Organisation||Department of Gastroenterology & Hepatology|
Scholten, L. (Lianne), Latenstein, A.E.J. (Anouk EJ), Aalfs, C.M, Bruno, M.J, Busch, O.R.C, Bonsing, B.A, … Besselink, M.G. (2020). Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables. United European Gastroenterology Journal. doi:10.1177/2050640620945534