Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.

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doi.org/10.1128/JVI.75.14.6687-6691.2001, hdl.handle.net/1765/12928
Journal of Virology
Erasmus MC: University Medical Center Rotterdam

Rimmelzwaan, G.F, van Amerongen, G, Bestebroer, T.M, Fouchier, R.A.M, Osterhaus, A.D.M.E, & Kuiken, T. (2001). Pathogenesis of influenza A (H5N1) virus infection in a primate model. Journal of Virology, 75(14), 6687–6691. doi:10.1128/JVI.75.14.6687-6691.2001