Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.

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Journal of Virology
Erasmus MC: University Medical Center Rotterdam

Rimmelzwaan, G., van Amerongen, G., Bestebroer, T., Fouchier, R., Osterhaus, A., & Kuiken, T. (2001). Pathogenesis of influenza A (H5N1) virus infection in a primate model. Journal of Virology, 75(14), 6687–6691. doi:10.1128/JVI.75.14.6687-6691.2001