Aim: To investigate the relationship between the diabetes-specific dementia risk score (DSDRS) and concurrent and future cognitive impairment (CI) in type 2 diabetes (T2D). Methods: DSDRS were calculated for participants with T2D aged ≥60 years from the CARMELINA-cognition substudy (ClinicalTrials.gov Identifier: NCT 01243424). Cognitive assessment included Mini-Mental State Examination (MMSE) and a composite attention and executive functioning score (A&E). The relation between baseline DSDRS and probability of CI (MMSE < 24) and variation in cognitive performance was assessed at baseline (n = 2241) and after 2.5 years follow-up in patients without baseline CI (n = 1312). Results: Higher DSDRS was associated with a higher probability of CI at baseline (OR = 1.17 per point, 95% CI 1.12–1.22) and follow-up (OR = 1.24 per point, 95% CI 1.14–1.35). Moreover, in patients without baseline CI, higher DSDRS was also associated with lower baseline cognitive performance (MMSE: F(1, 1930) = 47.07, p <.0001, R2 = 0.02); A&E z-score: (F(1, 1871) = 33.44 p <.0001, R2 = 0.02) and faster cognitive decline at follow-up (MMSE: F(3, 1279) = 38.41, p <.0001; A&E z-score: F(3, 1206) = 148.48, p <.0001). Conclusions: The DSDRS identifies patients with T2D at risk of concurrent as well as future CI. The DSDRS may thus be a supportive tool in screening strategies for cognitive dysfunction in patients with T2D.

Additional Metadata
Keywords Cognitive impairment, Dementia, Diabetes-specific dementia risk score, Type 2 diabetes
Persistent URL dx.doi.org/10.1016/j.jdiacomp.2020.107674, hdl.handle.net/1765/129329
Journal Journal of Diabetes and its Complications
Organisation Department of Neurology
Citation
Verhagen, C. (Chloë), Janssen, J. (Jolien), Exalto, L.G. (Lieza G.), van den Berg, E, Johansen, O.E. (Odd Erik), & Biessels, G.J. (2020). Diabetes-specific dementia risk score (DSDRS) predicts cognitive performance in patients with type 2 diabetes at high cardio-renal risk. Journal of Diabetes and its Complications. doi:10.1016/j.jdiacomp.2020.107674