Objective: Smoking cessation is associated with weight gain. We first examined the associations of smoking cessation in early-pregnancy with gestational weight gain and subsequently evaluated the risks of pregnancy complications among women who quit smoking in early-pregnancy according to their gestational weight gain. Methods: In a population-based prospective cohort study among 7,389 women, we measured weight in each pregnancy period. Information on smoking and pregnancy complications was obtained from questionnaires and medical records. Results: As compared to continued smoking during pregnancy, smoking cessation in early-pregnancy was not associated with gestational weight gain. Smoking cessation in early-pregnancy was associated with decreased risks of delivering small-for-gestational-age infants (Odds Ratio (OR) 0.52 (95 % Confidence Interval (CI) 0.37, 0.75)), but with increased risks of pre-eclampsia (OR 2.07 (95 % CI 1.01, 4.27)) and delivering large-for-gestational-age infants (OR 2.11 (95 % CI 1.45, 3.09)). Among women who quit smoking in early-pregnancy with >12 kg weight gain, the risks of pre-eclampsia and delivering large-for-gestational-age infants were slightly increased. Conclusion: As compared to continued smoking during pregnancy, smoking cessation in early-pregnancy is not associated with increased gestational weight gain. Among women who quit smoking in early-pregnancy, higher gestational weight gain does not strongly affect their risks of pregnancy complications.

Additional Metadata
Keywords Pregnancy, Pregnancy complications, Smoking cessation, Weight gain
Persistent URL dx.doi.org/10.1016/j.ejogrb.2020.07.040, hdl.handle.net/1765/129340
Journal European Journal of Obstetrics & Gynecology and Reproductive Biology
Citation
Al-Hassany, L. (Lina), Wahab, R.J. (Rama J.), Steegers, E.A.P, Jaddoe, V.W.V, & Gaillard, R. (2020). Smoking cessation in early-pregnancy, gestational weight gain and subsequent risks of pregnancy complications. European Journal of Obstetrics & Gynecology and Reproductive Biology, 253, 7–14. doi:10.1016/j.ejogrb.2020.07.040