Cell therapy with mesenchymal stem cells stands at the front line of new potential tolerance-inducing therapies in solid organ transplantation. Pre-clinical and in vitro models have shown very potent immunomodulatory effects of MSC, and the first clinical trials hold promising perspectives. On the other hand, new approaches around the therapeutic use of MSC are also under research. In this article, we review recent evidence on MSC immunomodulation and their clinical application. We further discuss and speculate about new lines of research in the field including new applications and alternatives or variations of the cell product.

Additional Metadata
Keywords B cells, Exosomes, Extracellular vesicles, Mesenchymal stem cells, Tolerance, Transplantation
Persistent URL dx.doi.org/10.1007/s40472-015-0053-x, hdl.handle.net/1765/130077
Journal Current Transplantation Reports
Citation
Franquesa, M, Merino, A. (Ana), & Grinyo, J. (2015). New Steps in the Use of Mesenchymal Stem Cell in Solid Organ Transplantation. Current Transplantation Reports, 2(2), 184–190. doi:10.1007/s40472-015-0053-x