Circulating metabolites are associated with brain atrophy and white matter hyperintensities
Introduction: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.
|Keywords||Alzheimer's disease, cholesterol, glucose, lipids, magnetic resonance imaging (MRI), metabolism|
|Persistent URL||dx.doi.org/10.1002/alz.12180, hdl.handle.net/1765/130157|
|Journal||Alzheimer's & Dementia|
de Leeuw, F.A. (Francisca A.), Karamujić-Čomić, H. (Hata), Tijms, B.M. (Betty M.), Peeters, C.F.W, Kester, M.I. (Maartje I.), Scheltens, P, … van der Flier, W.M. (2020). Circulating metabolites are associated with brain atrophy and white matter hyperintensities. Alzheimer's & Dementia. doi:10.1002/alz.12180