Disadvantage of Small (<60 kg) Adult Candidates on the Liver Transplantation Waitlist
Background: Small adult patients with lower bodyweight wait-listed for liver transplantation may face a shortage of size-matched whole-liver grafts. The objective of this study is to compare time to transplantation in adult patients with a bodyweight of <60 kg to patients with bodyweight ≥60 kg. Methods: A matched case–control study was conducted. Patients aged 18 years and older listed for liver transplantation at our transplant center, from 2007 to 2016 with a bodyweight <60 kg were manually matched 1:2 to control patients ≥ 60 kg. Matching was performed based on ABO blood type, model for end-stage liver disease score, (non)-standard exception status, and eligibility for donation after cardiac death. Time to transplantation was assessed with univariable Cox-regression. Results: In total, 23 cases with a bodyweight < 60 kg were matched to 46 average-sized control patients. Small adults were significantly disadvantaged for receiving a liver transplantation as compared to their average-sized counterpart (hazard ratio 0.47; 95% confidence interval 0.29-0.75, P =.002). At the end of follow-up, 14/23 (60.9%) of cases versus 35/46 of controls (76.1%) had received a liver transplantation. Conclusion: Small adults with a bodyweight below 60 kg are disadvantaged on the waitlist for a size-matched whole liver graft.
|Keywords||allocation, liver transplant recipient, liver transplantation, waitlist, waitlist allocation|
|Persistent URL||dx.doi.org/10.1177/1526924820958142, hdl.handle.net/1765/130427|
|Journal||Progress in Transplantation|
van Dijk, A.-B.R.M. (Anne-Baue R. M.), Sneiders, D, Murad, S.D. (Sarwa Darwish), Polak, W.G, & Hartog, H. (2020). Disadvantage of Small (<60 kg) Adult Candidates on the Liver Transplantation Waitlist. Progress in Transplantation. doi:10.1177/1526924820958142