Development of novel nanomedicines based on antimicrobial peptides for the treatment of multidrug-resistant Gram-negative pneumonia
Ontwikkeling van nieuwe nanogeneesmiddelen gebaseerd op antimicrobiële peptiden ter behandeling van multidrug-resistente Gram-negatieve longinfectie
The research described in this thesis comprises the development of novel inhalable antibiotic-nanomedicines based on antimicrobial peptides for the treatment of lung infections caused by multidrug-resistant Gram-negative bacteria like Klebsiella pneumonia. In our research, we first show that these two antimicrobial peptides are effective in the treatment of the most resistant bacteria causing infections, and then used an experimental animal model to show that the novel nanomedicines have improved characteristics, notably fewer side effects and a longer residence time in the lungs.
|Keywords||nanomedicine, antimicrobial peptides, antibiotic resistance, pneumonia|
|Promotor||A. Verbon (Annelies) , J.P. Hays (John) , I.A.J.M. Bakker-Woudenberg (Irma)|
|Publisher||Erasmus University Rotterdam|
van der Weide, H. (2020, September 30). Development of novel nanomedicines based on antimicrobial peptides for the treatment of multidrug-resistant Gram-negative pneumonia. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/130462