Through the systematic application of various advanced light microscopy techniques, including super-resolution microscopy, we have described in greater detail the dynamic structure of focal adhesions, protein complexes through which cells attach to a surface. We show that the dynamics of focal adhesion proteins correlate with the position and orientation of a focal adhesion within the cell, that focal adhesions around the actin fibre attachment site have a higher density than other areas of the focal adhesion and that the ends of focal adhesions have a unique protein structure.

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A.B. Houtsmuller (Adriaan) , W.A. van Capellen (Gert)
Erasmus University Rotterdam
Department of Pathology

Legerstee, K. (2020, September 29). Multimodal Microscopy of Focal Adhesions. Erasmus University Rotterdam. Retrieved from