This thesis is mainly focused on dosing evaluation of old antibiotics using parametric and nonparametric population pharmacokinetic models. Additionally, modelling-related challenges during dosing evaluation were identified and recommendations on the use of these models during drug development and in clinical practise were set up.

Additional Metadata
Keywords beta-lactam, antibiotics, pharmacokinetics, dosing
Promotor J.W. Mouton (Johan) , T. van Gelder (Teun) , B.C.P. Koch (Birgit) , A.E. Muller (Anouk)
Publisher Erasmus University Rotterdam
ISBN 978-94-6332-620-9
Persistent URL
Note For copyright reasons there is a partial embargo for this dissertation
Organisation Department of Pharmacy
de Velde, F. (2020, October 14). Dosing Optimization of Beta-Lactam Antibiotics using Parametric and Nonparametric Population Pharmacokinetic Models. Erasmus University Rotterdam. Retrieved from