This thesis is mainly focused on dosing evaluation of old antibiotics using parametric and nonparametric population pharmacokinetic models. Additionally, modelling-related challenges during dosing evaluation were identified and recommendations on the use of these models during drug development and in clinical practise were set up.

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J.W. Mouton (Johan) , T. van Gelder (Teun) , B.C.P. Koch (Birgit) , A.E. Muller (Anouk)
Erasmus University Rotterdam
Department of Pharmacy

de Velde, F. (2020, October 14). Dosing Optimization of Beta-Lactam Antibiotics using Parametric and Nonparametric Population Pharmacokinetic Models. Retrieved from