Background and Objective Non-participation in colorectal cancer (CRC) screening needs to be decreased to achieve its full potential as a public health strategy. To facilitate successful implementation of CRC screening towards unscreened individuals, this study aimed to quantify the impact of screening and individual characteristics on non-participation in CRC screening. Methods An online discrete choice experiment partly based on qualitative research was used among 406 representatives of the Dutch general population aged 55–75 years. In the discrete choice experiment, respondents were ofered a series of choices between CRC screening scenarios that difered on fve characteristics: efectiveness of the faecal immunochemical screening test, risk of a false-negative outcome, test frequency, waiting time for faecal immunochemical screening test results and waiting time for a colonoscopy follow-up test. The discrete choice experiment data were analysed in a systematic manner using random-utility-maximisation choice processes with scale and/or preference heterogeneity (based on 15 individual characteristics) and/or random intercepts. Results Screening characteristics proved to infuence non-participation in CRC screening (21.7–28.0% non-participation rate), but an individual’s characteristics had an even higher impact on CRC screening non-participation (8.4–75.5% nonparticipation rate); particularly the individual’s attitude towards CRC screening followed by whether the individual had participated in a cancer screening programme before, the decision style of the individual and the educational level of the individual. Our fndings provided a high degree of confdence in the internal–external validity. Conclusions This study showed that although screening characteristics proved to infuence non-participation in CRC screening, a respondent’s characteristics had a much higher impact on CRC screening non-participation. Policy makers and physicians can use our study insights to improve and tailor their communication plans regarding (CRC) screening for unscreened individuals.,
The Patient: patient-centered outcomes research
Institute for Medical Technology Assessment (iMTA)

de Bekker-Grob, E.W, Donkers, Bas, Veldwijk, Jorien, Jonker, M.F, Buis, Sylvia, Huisman, Jan, & Bindels, Patrick. (2020). What Factors Influence Non‑Participation Most in Colorectal Cancer Screening? A Discrete Choice Experiment. The Patient: patient-centered outcomes research. doi:10.1007/s40271-020-00477-w