Haemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory condition that can be triggered by infections, malignancies, or auto-immune diseases. Here, we present a patient with rapidly progressive HLH triggered by a herpes simplex virus type 2 (HSV-2) primary infection. The patient was successfully treated with intravenous high-dose acyclovir, immunoglobulins, and dexamethasone. This is the first report of HSV-2-associated HLH in an immunocompetent adult patient.

Haemophagocytic lymphohistiocytosis, HSV-2
hdl.handle.net/1765/131353
The Netherlands Journal of Medicine
Department of Virology

Jongbloed, E.M., Hermans, M.A.W., Wabbijni, M., van Kampen, J.J.A., & van Laar, J.A.M. (2020). HLH caused by an HSV-2 infection: a case report and review of the literature. The Netherlands Journal of Medicine, 78(5), 282–285. Retrieved from http://hdl.handle.net/1765/131353