A soluble form of the interleukin-2 receptor (sIL-2R) is secreted upon T-cell activation. Increased blood levels of sIL-2R occur in a variety of immunological diseases. Although the biological function of sIL-2R is incompletely understood, both in health and disease, sIL-2R serum measurements are commonly conducted in clinical practice as it may help to facilitate diagnosis of specific immune-mediated diseases, such as haemophagocytic lymphohistiocytosis and sarcoidosis. In these, and in other immune-diseases, sIL-2R levels may be used as a biomarker to monitor/predict disease activity and treatment response. In this review, we will give a brief overview of the biology of the IL-2/IL-2R system and will subsequently discuss the clinical utility of sIL-2R measurement, especially in the context of haemophagocytic lymphohistiocytosis, sarcoidosis, rheumatoid arthritis, systemic lupus erythematosus, juvenile idiopathic arthritis, adult-onset Still’s disease, ANCA-associated vasculitis, and IgG4-related disease.

Haemophagocytic lymphohistiocytosis, immune-mediated, diseases, sarcoidosis, soluble IL-2 receptor, T-cell activation
The Netherlands Journal of Medicine
Department of Immunology

Dik, W.A, & Heron, M. (2020). Clinical significance of soluble interleukin-2 receptor measurement in immune-mediated diseases. The Netherlands Journal of Medicine, 78(5), 220–231. Retrieved from http://hdl.handle.net/1765/131362