Axonal arbors in many neuronal networks are exuberant early during development and become refined by activity-dependent competitive mechanisms. Theoretical work proposed non-competitive interactions between co-active axons to co-stabilize their connections, but the demonstration of such interactions is lacking. Here, we provide experimental evidence that reducing cyclic AMP (cAMP) signaling in a subset of retinal ganglion cells favors the elimination of thalamic projections from neighboring neurons, pointing to a cAMP-dependent interaction that promotes axon stabilization.

dx.doi.org/10.1016/j.celrep.2020.108220, hdl.handle.net/1765/131369
Cell Reports

Louail, A., Sierksma, M.C., Chaffiol, A., Baudet, S., Assali, A., Couvet, S., … Nicol, X. (2020). cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons. Cell Reports, 33(1). doi:10.1016/j.celrep.2020.108220