Patients who undergo transcatheter aortic valve replacement often are frail and elderly. Delirium is a frequently observed complication, associated with impaired recovery, prolonged hospital stay, and mortality. In different hospital settings, interventions that reduced the incidence of delirium resulted in improved clinical outcome and reduced costs. In that context, prevention, early recognition, and timely interventions could be the next step toward better outcomes of transcatheter aortic valve replacement. This review is focused on awareness and recognition of delirium, including predisposing “vulnerability” factors (such as cognitive impairment and carotid artery disease) and “trigger” factors (such as anesthesia, hemodynamic imbalance, and complications). For prevention and treatment, clinicians should focus on sleep hygiene, orientation, pain management, and early mobilization. In case of delirium, a thorough search and treatment of trigger factors is warranted. Future studies should focus on risk assessment, preventive and therapeutic interventions, and their potential benefit in terms of costs and clinical outcomes. (J Am Coll Cardiol Intv 2020;13:2453–66) © 2020 by the American College of Cardiology Foundation.

dx.doi.org/10.1016/j.jcin.2020.07.044, hdl.handle.net/1765/132017
JACC: Cardiovascular Interventions
Department of Cardiology

van der Wulp, K., van Wely, M.H., Rooijakkers, M.J.P., Brouwer, M.A.E., Boogaard, M.W, Pickkers, P, … Royen, N. (2020). Delirium After TAVR Crosspassing the Limit of Resilience. JACC: Cardiovascular Interventions, 13(21), 197–2466. doi:10.1016/j.jcin.2020.07.044