Dual-function MR-guided hyperthermia: An innovative integrated approach and experimental demonstration of proof of principle
Temperature monitoring plays a central role in improving clinical effectiveness of adjuvant hyperthermia. The potential of magnetic resonance thermometry for treatment monitoring purposes led to several MR-guided hyperthermia approaches. However, the proposed solutions were sub-optimal due to technological and intrinsic limitations. These hamper achieving target conformal heating possibilities (applicator limitations) and accurate thermometry (inadequate signal-to-noise-ratio (SNR)). In this work, we studied proof of principle of a dual-function hyperthermia approach based on a coil array (64 MHz, 1.5 T) that is integrated in-between a phased array for heating (434 MHz) for maximum signal receive in order to improve thermometry accuracy. Hereto, we designed and fabricated a superficial hyperthermia mimicking planar array setup to study the most challenging interactions of generic phased-array setups in order to validate the integrated approach. Experiments demonstrated that the setup complies with the superficial hyperthermia guidelines for heating and is able to improve SNR at 2-4 cm depth by 17%, as compared to imaging using the body coil. Hence, the results showed the feasibility of our dual-function MR-guided hyperthermia approach as basis for the development of application specific setups.
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|I E E E Transactions on Biomedical Engineering|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Sumser, K. (Kemal), Bellizzi, G.G. (Gennaro G.), Forner, R. (Ria), Drizdal, T, Hernandez Tamames, J.A. (Juan A.), van Rhoon, G.C, & Paulides, M.M. (2020). Dual-function MR-guided hyperthermia: An innovative integrated approach and experimental demonstration of proof of principle. I E E E Transactions on Biomedical Engineering. doi:10.1109/tbme.2020.3012734