The Crossroad of Phosphatase and Kinase Signaling in Cancer

Treatment and survival of cancer has improved remarkably over the last decades. In particular the advent of targeted therapies, including cell cycle inhibitors, kinase inhibitors and others, have improved outcomes of several types of cancer. However, tumor relapse due to resistance acquisition is often observed and a better understanding of cancer signaling in order to devise novel targeted treatment strategies is thus still required.
The aim of this thesis was to further investigate phosphorylation events in different malignancies and determine whether low molecular weight protein tyrosine phosphatase could potentially be a target for treatment.