Treatment and survival of cancer has improved remarkably over the last decades. In particular the advent of targeted therapies, including cell cycle inhibitors, kinase inhibitors and others, have improved outcomes of several types of cancer. However, tumor relapse due to resistance acquisition is often observed and a better understanding of cancer signaling in order to devise novel targeted treatment strategies is thus still required.
The aim of this thesis was to further investigate phosphorylation events in different malignancies and determine whether low molecular weight protein tyrosine phosphatase could potentially be a target for treatment.

M.P. Peppelenbosch (Maikel) , prof.dr. C.V. Ferreira-Halder, G.M. Fuhler (Gwenny)
Centre for Local Democracy
The research was funded by: Brazilian Council for Scientific and Technological Development CNPq, Coordination for the Improvement of Higher Education Personnel CAPES, São Paulo Research Foundation FAPESP
For copyright reasons there is a partial embargo for this dissertation
Department of Gastroenterology & Hepatology

de Sousa Faria, A.V. (2020, November 26). The Crossroad of Phosphatase and Kinase Signaling in Cancer. Centre for Local Democracy. Retrieved from