BACKGROUND: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis. METHODS: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E. RESULTS: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections. CONCLUSIONS: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis.

anterior ischemic optic neuropathy, giant cell arteritis, immunohistochemistry nonspecific staining, temporal arterial biopsies, varicella-zoster virus,
The Journal of Infectious Diseases
Department of Pathology

Verdijk, R.M, Ouwendijk, W.J.D, Kuijpers, R.W.A.M, & Verjans, G.M.G.M. (2021). No Evidence of Varicella-Zoster Virus Infection in Temporal Artery Biopsies of Anterior Ischemic Optic Neuropathy Patients With and Without Giant Cell Arteritis. The Journal of Infectious Diseases, 223(1), 109–112. doi:10.1093/infdis/jiaa566