Objective: Long-term weight loss is important and difficult to achieve for many women with polycystic ovary syndrome (PCOS). Lifestyle interventions (LS) in PCOS have shown moderate short-term effects. Three-component LS that combine nutrition advice, exercise, and cognitive behavioral therapy have not been tested in long-term interventions. Methods: Women (N=183) with PCOS who were trying to conceive and had BMI>25 kg/m2 were assigned to 20 group sessions of cognitive behavioral therapy combined with nutrition advice and exercise (LS with or without Short Message Service [SMS] via mobile phone) or care as usual (CAU). Results: More weight loss was observed in LS than in CAU (P<0.001). Adding SMS was even more effective (P=0.017). In CAU, 13 of 60 (21.8%) succeeded in achieving a 5% weight loss, as did 32 of 60 (52.8%) in LS without SMS and 54 of 63 (85.7%) in LS with SMS. The odds of achieving a 5% weight loss were 7.0 (P<0.001) in LS compared with CAU. More than 18 of 60 (29.0%) of the women in CAU gained weight versus 5 of 60 (8.5%) and 2 of 63 (3.1%) in LS without or with SMS, respectively. The overall dropout rate was 116 of 183 (63.4%). Conclusions: A three-component LS program resulted in reasonable weight loss in women with PCOS. Adding SMS resulted in more weight loss.

dx.doi.org/10.1002/oby.22980, hdl.handle.net/1765/133839
Obesity: a research journal
Department of Medical Psychology and Psychotherapy

Jiskoot, G., Timman, R, Beerthuizen, A, Dietz de Loos, A., van Busschbach, J.J, & Laven, J.S.E. (2020). Weight Reduction Through a Cognitive Behavioral Therapy Lifestyle Intervention in PCOS: The Primary Outcome of a Randomized Controlled Trial. Obesity: a research journal, 28(11), 2134–2141. doi:10.1002/oby.22980