Since the advent of direct-acting antivirals, elimination of hepatitis C viral (HCV) infections seems within reach. However, studies on the HCV cascade of care show suboptimal progression through each step for all patient groups. Loss to follow-up (LTFU) is a major issue and is a barrier to HCV elimination. This review summarizes the scale of the LTFU problem and proposes a micro-elimination approach. Retrieving LTFU patients and re-engaging them with care again has shown to be feasible in the Netherlands. Micro-elimination through retrieval can contribute to reaching the World Health Organization's viral hepatitis elimination targets by 2030.

cascade of care, hepatitis C, lost to follow-up, micro-elimination,
Journal of Viral Hepatitis

Van Dijk, M, Drenth, J.P.H, Arends, J.E.A., Brakenhoff, S.M., Isfordink, C.J., de Knegt, R., & van der Valk, M. (2020). Loss to follow-up in the hepatitis C care cascade: A substantial problem but opportunity for micro-elimination. Journal of Viral Hepatitis, 27(12), 1270–1283. doi:10.1111/jvh.13399