Context: Patients with craniopharyngioma suffer from obesity and impaired bone health. Little is known about longitudinal changes in body composition and bone mineral density (BMD). Objective: To describe body composition and BMD (change). Design: Retrospective longitudinal study. Setting: Two Dutch/Swedish referral centers. Patients: Patients with craniopharyngioma (n = 112) with a dual X-ray absorptiometry (DXA) scan available (2 DXA scans, n = 86; median Δtime 10.0 years; range 0.4-23.3) at age ≥ 18 years (58 [52%] male, 50 [45%] childhood onset). Main outcome measures: Longitudinal changes of body composition and BMD, and associated factors of ΔZ-score (sex and age standardized). Results: BMI (from 28.8 ± 4.9 to 31.2 ± 5.1 kg/m2 , P < .001), fat mass index (FMI) (from 10.5 ± 3.6 to 11.9 ± 3.8 kg/m2 , P = .001), and fat free mass index (FFMI) (from 18.3 ± 3.2 to 19.1 ± 3.2 kg/m2 , P < .001) were high at baseline and increased. Fat percentage and Z-scores of body composition did not increase, except for FFMI Z-scores (from 0.26 ± 1.62 to 1.06 ± 2.22, P < .001). Z-scores of total body, L2-L4, femur neck increased (mean difference 0.61 ± 1.12, P < .001; 0.74 ± 1.73, P < .001; 0.51 ± 1.85, P = .02). Linear regression models for ΔZ-score were positively associated with growth hormone replacement therapy (GHRT) (femur neck: beta 1.45 [95% CI 0.51–2.39]); and negatively with radiotherapy (femur neck: beta –0.79 [–1.49 to –0.09]), glucocorticoid dose (total body: beta –0.06 [–0.09 to –0.02]), and medication to improve BMD (L2-L4: beta –1.06 [–1.84 to –0.28]). Conclusions: Z-scores of BMI, fat percentage, and FMI remained stable in patients with craniopharyngioma over time, while Z-scores of FFMI and BMD increased. Higher glucocorticoid dose and radiotherapy were associated with BMD loss and GHRT with increase.

craniopharyngioma, DXA, body composition, sarcopenia, bone mineral density, longitudinal study
dx.doi.org/10.1210/clinem/dgaa607, hdl.handle.net/1765/133889
Journal of Clinical Endocrinology and Metabolism
Department of Internal Medicine

van Santen, S.S., Olsson, D.S., Hammarstrand, C., Wijnen, M., Fiocco, M, van den Heuvel-Eibrink, M.M., … Neggers, S.J.C.M.M. (2020). Body composition and bone mineral density in craniopharyngioma patients: A longitudinal study over 10 years. Journal of Clinical Endocrinology and Metabolism, 105(12). doi:10.1210/clinem/dgaa607