A ubiquitin ligase toggles red cell differentiation

In this issue of Blood, Xu et al report on a novel regulator of red cell differentiation, F-box only protein 11 (FBXO11), that removes transcriptional repressors from erythroid genes releasing their expression by targeting the chromatin-associated protein bromo adjacent homology domain–containing 1 (BAHD1) for degradation.1

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