In this thesis, I first established that rotavirus may be one of the causal factors with respect to biliary atresia, which also emphasized the importance of investigating rotavirus infection and further illustrates the desperate need of novel antiviral treatment. Consequentially, we aimed at discovering anti-rotavirus strategies through targeting the interferon pathway, by inhibition of the nucleotide synthesis pathways and through broad-spectrum antiviral agents screening, respectively. These strategies provided insight to new antiviral drug development and provide a window to better treatment.

Rotavirus, Biliary Atresia, Viral-host Interaction, Nucleotide Biosynthesis, Organoids
M.P. Peppelenbosch (Maikel) , Q. Pan (Qiuwei)
Erasmus University Rotterdam
The research was funded by China Scholarship Council
Department of Gastroenterology & Hepatology

Chen, S. (2020, December 15). Facing the resurgence of rotavirus: Development of novel antiviral agents. Erasmus University Rotterdam. Retrieved from