Facing the resurgence of rotavirus: Development of novel antiviral agents

In this thesis, I first established that rotavirus may be one of the causal factors with respect to biliary atresia, which also emphasized the importance of investigating rotavirus infection and further illustrates the desperate need of novel antiviral treatment. Consequentially, we aimed at discovering anti-rotavirus strategies through targeting the interferon pathway, by inhibition of the nucleotide synthesis pathways and through broad-spectrum antiviral agents screening, respectively. These strategies provided insight to new antiviral drug development and provide a window to better treatment.