Objective: The purpose of this study was to investigate the associations of urinary phthalates and bisphenols at age 6 years old with body fat and cardiovascular risk factors at 6 and 10 years and with the change from 6 to 10 years. Methods: Among 471 Dutch children, the phthalates and bisphenols urinary concentrations at 6 years and BMI, fat mass index, android fat mass, blood pressure, glucose, insulin, and lipids blood concentrations at 6 and 10 years were measured. Results: An interquartile range increase in di-n-octyl phthalate (DNOP) metabolites concentrations at 6 years was associated with an increased risk of overweight at 6 and 10 years (odds ratio: 1.44; 95% CI: 1.11-1.87, and 1.43; 95% CI: 1.09-1.86, respectively). Also, higher DNOP metabolites concentrations were associated with higher fat mass index at 6 years, higher systolic blood pressure at 10 years, a decrease in highdensity lipoprotein cholesterol, and an increase in triglycerides concentrations from 6 to 10 years (P<0.05). Higher total bisphenols and bisphenol A concentrations were associated with a decrease in BMI from 6 to 10 years (P<0.01). Conclusions: DNOP metabolites are associated with overweight and an adverse cardiovascular profile in childhood. Total bisphenols and bisphenol A are associated with a decrease in BMI from 6 to 10 years.

doi.org/10.1002/oby.23082, hdl.handle.net/1765/134528
Obesity: a research journal
Department of Pediatrics

Silva, C.C.V., Jaddoe, V., Sol, C.M., El Marroun, H., Martinez-Moral, M.P., Kannan, K., … Santos, S. (2021). Phtalate and bisphenol urinary concentrations, body fat measures and cardiovascular risk factors in dutch school-age children. Obesity: a research journal, 29(2), 409–417. doi:10.1002/oby.23082