2020-12-18
Immunity in Breast Cancer: Charting T cell evasion and exploring new targets for T cells
Publication
Publication
Immuniteit in borst kanker: In kaart brengen van T cel evasie en verkenning van nieuwe targets voor T cellen
Cancer immunotherapy of breast cancer is currently challenged by low response rates and lack of predictive markers for immune therapies; lack of druggable targets that counteract T cell evasion; and lack of safe and effective target antigens for adoptive T cell therapies. In Part 1 of this thesis (Chapter2-4) we focused on the knowledge gap regarding T cell evasive mechanisms, which, provides a basis for patient stratification and selection of combination therapies. In Part 2 of this thesis (Chapter 5-7) we focused on the identification and selection of safe and effective target antigens and corresponding TCRs for adoptive T cell therapy for TNBC (one of the subtypes of breast cancer)
| Additional Metadata | |
|---|---|
| , , , , , , | |
| These studies were funded by the Dutch Cancer Society (Alpe d’HuZes/KWF 2014-7087) | |
| J.E.M.A. Debets (Reno) , J.W.M. Martens (John) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/134597 | |
| Organisation | Department of Medical Oncology |
|
Hammerl, D. (2020, December 18). Immunity in Breast Cancer: Charting T cell evasion and exploring new targets for T cells. Retrieved from http://hdl.handle.net/1765/134597 |
|
