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Brouwer, P.J.M. (Philip J.M.), Brinkkemper, M. (Mitch), Maisonnasse, P. (Pauline), Dereuddre-Bosquet, N. (Nathalie), Grobben, M. (Marloes), Claireaux, M. (Mathieu), de Gast, M. (Marlon), Marlin, R. (Romain), Chesnais, V. (Virginie), Diry, S. (Ségolène), et al. Allen, J.D. (Joel D.), Watanabe, Y. (Yasunori), Giezen, J.M. (Julia M.), Kerster, G. (Gius), Turner, H.L. (Hannah L.), van der Straten, K. (Karlijn), van der Linden, C.A. (Cynthia A.), Aldon, Y. (Yoann), Naninck, T. (Thibaut), I. Bontjer (Ilja), Burger, J.A. (Judith A.), Poniman, M. (Meliawati), Mykytyn, A.Z. (Anna Z.), N.M.A. Okba (Nisreen), Schermer, E.E. (Edith E.), M.J. van Breemen (Mariëlle), Ravichandran, R. (Rashmi), Caniels, T.G. (Tom G.), van Schooten, J. (Jelle), Kahlaoui, N. (Nidhal), Contreras, V. (Vanessa), Lemaître, J. (Julien), Chapon, C. (Catherine), Fang, R.H.T. (Raphaël Ho Tsong), Villaudy, J. (Julien), Sliepen, K. (Kwinten), van der Velden, Y.U. (Yme U.), B.L. Haagmans (Bart), de Bree, G.J. (Godelieve J.), Ginoux, E. (Eric), Ward, A.B. (Andrew B.), Crispin, M. (Max), King, N.P. (Neil P.), S. van der Werf (Sylvie), van Gils, M.J. (Marit J.), Le Grand, R. (Roger) and Sanders, R.W. (Rogier W.)

2021

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

Publication

Publication

Cell

Brouwer et al. present preclinical evidence in support of a COVID-19 vaccine candidate, designed as a self-assembling two-component protein nanoparticle displaying multiple copies of the SARS-CoV-2 spike protein, which induces strong neutralizing antibody responses and protects from high-dose SARS-CoV-2 challenge.The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.

Additional Metadata
Keywords antibodies, B cells, COVID-19, immunity, macaques, nanoparticles, protection, SARS-CoV-2, vaccine
Persistent URL doi.org/10.1016/j.cell.2021.01.035, hdl.handle.net/1765/134906
Journal Cell
Organisation Department of Virology
Citation
Brouwer, P.J.M. (Philip J.M.), Brinkkemper, M. (Mitch), Maisonnasse, P. (Pauline), Dereuddre-Bosquet, N. (Nathalie), Grobben, M. (Marloes), Claireaux, M. (Mathieu), … Sanders, R.W. (Rogier W.). (2021). Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection. Cell. doi:10.1016/j.cell.2021.01.035
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