This thesis aimed to provide more insight into safety aspects and efficacy of current medical immunosuppressive treatment in inflammatory bowel disease and several opportunities to improve IBD care. To increase the chance of patients responding to a treatment, it is important to identify patients that are prone to treatment failure. We addressed risk factors for therapy withdrawal due to ineffectiveness and adverse events in current anti-inflammatory treatment for IBD. Special consideration was given to female IBD patients regarding the risk of cervical abnormalities and sex-related differences in drug efficacy and tolerability. We also focused on opportunities in rectal treatment and monitoring of IBD patients to reduce treatment-related burden.

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C.J. van der Woude (Janneke)
Erasmus University Rotterdam
Department of Gastroenterology & Hepatology

Kreijne, J. (2021, January 27). Safety and Efficacy of Inflammatory Bowel Disease Treatment: a challenging balance. Retrieved from