This thesis describes novel insights into pathophysiological mechanisms in pulmonary hypertension as a result of problems of the left heart. The author investigated why some patients deteriorate, even when the initial cause of the disease is cured. Furthermore, several pharmacotherapeutic approaches to stop the deterioration were tested.

pulmonary hypertension, heart failure, endothelin, nitric oxide, vascular remodeling, right ventricular remodeling, physiology, animal research, vasoconstrictie, vasodilatatie, pulmonale hypertensie, hartfalen, endotheline, stikstof oxide, vaatremodellering, rechter ventrikel remodellering, fysiologie, proefdierkunde, vasoconstrictie, vasodilatatie
D.J.G.M. Duncker (Dirk) , D. Merkus (Daphne)
Erasmus University Rotterdam
Department of Cardiology

van Duin, R.W.B. (2021, March 30). Novel insights into the Pathophysiology of Group II Pulmonary Hypertension Impact on the pulmonary vasculature and right ventricle. Erasmus University Rotterdam. Retrieved from