Pancreatic neuroendocrine neoplasms are rare tumors of which the genetic constitution is not fully understood. In addition, resistance against everolimus, a frequently used treatment modality, forms a clinical challenge in these tumors. This thesis contains studies on the genetic make-up of pancreatic neuroendocrine tumors, the mechanisms of everolimus resistance and how to overcome this resistance.

Neuroendocrine neoplasms, neuroendocrine tumors, neuroendocrine tumours, everolimus, treatment resistance, tumor heterogeneity, neuroendocrine tumor genetics, neuroendocriene neoplasiën, neuroendocrine tumoren, everolimus, everolimus resistentie, tumorheterogeniciteit, genetica van neuroendocriene tumoren
L.J. Hofland (Leo) , P. Pauwels (Patrick) , M. Peeters (Marc) , K.O. de Beeck (Ken Op)
Department of Internal Medicine

Vandamme, T.A.L. (2021, April 20). Pancreatic Neuroendocrine Neoplasms: from Genetics to Everolimus Resistance. Retrieved from