Pancreatic neuroendocrine neoplasms are rare tumors of which the genetic constitution is not fully understood. In addition, resistance against everolimus, a frequently used treatment modality, forms a clinical challenge in these tumors. This thesis contains studies on the genetic make-up of pancreatic neuroendocrine tumors, the mechanisms of everolimus resistance and how to overcome this resistance.

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L.J. Hofland (Leo) , P. Pauwels (Patrick) , M. Peeters (Marc) , K.O. de Beeck (Ken Op)
Department of Internal Medicine

Vandamme, T.A.L. (2021, April 20). Pancreatic Neuroendocrine Neoplasms: from Genetics to Everolimus Resistance. Retrieved from