Neurodegenerative diseases such as Alzheimer's disease are notoriously heterogeneous; pathologically as well as in their clinical presentation in patients. There are differences between patients in terms of the pathways of progression, the speed of progression, and the effect the progression has on the patient's cognition. This myriad of differences not only makes clinical diagnosis very challenging, but also has major implications for the efficacy of drug trials. As heterogeneous as these diseases are, there is an underlying order in their progression. An underlying method to their disruption of homeostasis. An underlying symphony leading to the cacophony.

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This work has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 666992 and from TKI-LSH Health Holland Alzheimer Nederland project (No. LSHM18049)
W.J. Niessen (Wiro)
Erasmus University Rotterdam
ASCI dissertation series
Department of Radiology

Venkatraghavan, V. (2021, June 8). The symphony of cacophony: understanding the order in neurodegenerative diseases (No. 415). ASCI dissertation series. Retrieved from