Purpose<br/>Scleritis is a potentially blinding disorder, with highly unpredictable course and outcome. We analyzed the prevalence and clinical relevance of autoantibodies and inflammatory parameters in non-infectious scleritis.<br/><br/>Methods<br/>Retrospective analysis of laboratory findings in all consecutive patients at the department of Ophthalmology of the Erasmus MC with non-infectious scleritis.<br/><br/>Results<br/>We included 81 patients with non-infectious scleritis. A systemic autoimmune disease was present in 46%. Positive anti-nuclear antibodies were found in 30%, anti-neutrophil cytoplasmic antibodies were positive in 19%, and the presence of rheumatoid factor was shown in 17%. The aforementioned autoantibodies, as well as inflammatory parameters, failed to show prognostic clinical value. In contrast, anti-citrullinated peptide antibodies (ACPA), found in 9% of scleritis patients, were significantly associated with the development of scleral necrosis (P = .01).<br/><br/>Conclusions<br/>The presence of ACPA in patients with non-infectious scleritis was associated with the development of scleral necrosis.

doi.org/10.1080/09273948.2021.1966050, hdl.handle.net/1765/135753
Ocular Immunology and Inflammation
Erasmus MC: University Medical Center Rotterdam