2021-08-01
Autoimmune encephalitis
Publication
Publication
Journal of Neurology, Neurosurgery and Psychiatry , Volume 92 - Issue 8 p. 897- 907
<p>The objective of this paper is to evaluate available evidence for each step in autoimmune encephalitis management and provide expert opinion when evidence is lacking. The paper approaches autoimmune encephalitis as a broad category rather than focusing on individual antibody syndromes. Core authors from the Autoimmune Encephalitis Alliance Clinicians Network reviewed literature and developed the first draft. Where evidence was lacking or controversial, an electronic survey was distributed to all members to solicit individual responses. Sixty-eight members from 17 countries answered the survey. The most popular bridging therapy was oral prednisone taper chosen by 38% of responders while rituximab was the most popular maintenance therapy chosen by 46%. Most responders considered maintenance immunosuppression after a second relapse in patients with neuronal surface antibodies (70%) or seronegative autoimmune encephalitis (61%) as opposed to those with onconeuronal antibodies (29%). Most responders opted to cancer screening for 4 years in patients with neuronal surface antibodies (49%) or limbic encephalitis (46%) as opposed to non-limbic seronegative autoimmune encephalitis (36%). Detailed survey results are presented in the manuscript and a summary of the diagnostic and therapeutic recommendations is presented at the conclusion.</p>
| Additional Metadata | |
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| doi.org/10.1136/jnnp-2020-325302, hdl.handle.net/1765/135797 | |
| Journal of Neurology, Neurosurgery and Psychiatry | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Hesham Abboud, John C. Probasco, Sarosh Irani, Beau Ances, David R. Benavides, Michael Bradshaw, … M.J. (Maarten) Titulaer. (2021). Autoimmune encephalitis. Journal of Neurology, Neurosurgery and Psychiatry (Vol. 92, pp. 897–907). doi:10.1136/jnnp-2020-325302 |
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