<p>Hepatitis E virus (HEV) infection in immunocompromised patients, pregnant women and children requires treatment; however, no approved medication is currently available. The macrolide antibiotic azithromycin has been identified as a potent HEV inhibitor. Azithromycin inhibits HEV replication and viral protein expression in multiple cell culture models with genotype 1 and 3 strains. This is largely independent of its induction of an interferon-like response. Because it is safe and cheap, repurposing azithromycin for treating HEV infection is attractive, particularly in resource-limited settings.</p>

doi.org/10.1016/j.ijantimicag.2021.106383, hdl.handle.net/1765/135857
International Journal of Antimicrobial Agents
Erasmus MC: University Medical Center Rotterdam

Z. (Zhijiang) Miao, R. (Ruyi) Zhang, P. (Peifa) Yu, Y. (Yang) Li, Q. (Qiuwei) Pan, & Y. (Yunlong) Li. (2021). The macrolide antibiotic azithromycin potently inhibits hepatitis E virus in cell culture models. International Journal of Antimicrobial Agents, 58(3). doi:10.1016/j.ijantimicag.2021.106383