<p>Objective: This study assessed the short-term and the long-term breast cancer rate in patients with benign histopathologic results after a vacuum-assisted stereotactic biopsy (VASB) for calcifications. Methods: In a retrospective cohort study, all consecutive patients who had a benign diagnosis after VASB to analyze breast calcifications. Data of breast cancer development at short-term (four years) and long-term follow-up was gathered. Breast cancer rates in our cohort were compared to the breast cancer incidence in the general population. Results: Of 1376 patients who underwent VASB to analyze breast calcifications, 823 had a benign histopathologic diagnosis. During short-term follow-up, eight patients developed breast cancer. During the mean long-term follow-up period of 9.3 ± 3.1 years, 22 patients were diagnosed with ipsilateral breast cancer. The incidence rate of breast cancer after benign biopsy was comparable to the rate in the general population. Conclusion: In patients with VASB-confirmed benign calcifications of the breast, we found no excess incidence of ipsilateral breast cancer during ten years follow-up. Therefore, in patients with an increased risk of breast cancer (due to a history of breast cancer or familial risk) annual mammography should be sufficient. Patients with a population-based risk may be monitored via biennial mammography by the national screening program. More frequent screening would provide no benefit.</p>

doi.org/10.1016/j.breast.2021.06.008, hdl.handle.net/1765/136042
Erasmus MC: University Medical Center Rotterdam

Sara van Bekkum, Francina E.M. Dams, Pieter J. Westenend, J.M. (Joost) van Rosmalen, Marian B.E. Menke-Pluijmers, & Marc C.J.M. Kock. (2021). Ten years follow-up of histologically benign calcifications in the breast after vacuum-assisted stereotactic biopsy (VASB). Breast, 59, 135–143. doi:10.1016/j.breast.2021.06.008