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Dutch Autoimmune Hepatitis Study Group, M Biewenga, Xavier Verhelst, Martine A.M.C. Baven-Pronk, H Putter, Aad P. van den Berg, Karin C.M.J. van Nieuwkerk, H.R. (Henk) van Buuren, Gerd Bouma, Ynte S. de Boer, et al. Cedric Simoen, Isabelle Colle, J Schouten, Filip Sermon, Christophe van Steenkiste, Hans van Vlierberghe, A.J.P. (Adriaan) van der Meer, Frederik Nevens, Bart van Hoek, J. P.H. Drenth, NMF (Nicole) van Gerven, U Beuers, Karel J. van Erpecum, J (Judith) den Ouden, A Bhalla, JA Brouwer, JA (Jeroen) Vrolijk, G. H. Koek, M. M.J. Guichelaar, E. J. van der Wouden, J. J.M. van Meyel, L. C. Baak, C.R.A. (Ruud) Verdonk, M Klemt-Kropp, M. (Marit) Verhagen, JP Kuijvenhoven and HW de Jonge

2021-07-01

Development and validation of a prognostic score for long-term transplant-free survival in autoimmune hepatitis type 1

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Publication

United European Gastroenterology Journal , Volume 9 - Issue 6 p. 662- 671

<p>Background: No prognostic score is currently available for long-term survival in autoimmune hepatitis (AIH) patients. Objective: The aim of this study was to develop and validate such a prognostic score for AIH patients at diagnosis. Methods: The prognostic score was developed using uni- &amp; multivariate Cox regression in a 4-center Dutch cohort and validated in an independent 6-center Belgian cohort. Results: In the derivation cohort of 396 patients 19 liver transplantations (LTs) and 51 deaths occurred (median follow-up 118 months; interquartile range 60–202 months). In multivariate analysis age (hazard ratio [HR] 1.045; p &lt; 0.001), non-caucasian ethnicity (HR 1.897; p = 0.045), cirrhosis (HR 3.266; p &lt; 0.001) and alanine aminotransferase level (HR 0.725; p = 0.003) were significant independent predictors for mortality or LT (C-statistic 0.827; 95% CI 0.790–0.864). In the validation cohort of 408 patients death or LT occurred in 78 patients during a median follow-up of 74 months (interquartile range: 25–142 months). Predicted 5-year event rate did not differ from observed event rate (high risk group 21.5% vs. 15.7% (95% CI: 6.3%–24.2%); moderate risk group 5.8% versus 4.3% (95% CI: 0.0%–9.1%); low risk group 1.9% versus 5.4% (95% CI: 0.0%–11.4%); C-statistic 0.744 [95% CI 0.644–0.844]). Conclusions: A Dutch-Belgian prognostic score for long-term transplant-free survival in AIH patients at diagnosis was developed and validated.</p>

Additional Metadata
Persistent URL doi.org/10.1002/ueg2.12112, hdl.handle.net/1765/136056
Journal United European Gastroenterology Journal
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Dutch Autoimmune Hepatitis Study Group, M Biewenga, Xavier Verhelst, Martine A.M.C. Baven-Pronk, H Putter, Aad P. van den Berg, … HW de Jonge. (2021). Development and validation of a prognostic score for long-term transplant-free survival in autoimmune hepatitis type 1. United European Gastroenterology Journal, 9(6), 662–671. doi:10.1002/ueg2.12112


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