<p>Aim: To investigate longitudinal functional and neuropsychological outcomes 3–6 and 24 months after paediatric out-of-hospital cardiac arrest (OHCA). Further, to explore the association between paediatric cerebral performance category (PCPC) and intelligence. Methods: Prospective longitudinal single center study including children (0–17 years) with OHCA, admitted to the PICU of a tertiary care hospital between 2012 and 2017. Survivors were assessed during an outpatient multidisciplinary follow-up program 3–6 and 24 months post-OHCA. Functional and neuropsychological outcomes were assessed through interviews, neurological exam, and validated neuropsychological testing. Results: The total eligible cohort consisted of 49 paediatric OHCA survivors. The most common cause of OHCA was arrhythmia (33%). Median age at time of OHCA was 48 months, 67% were males. At 3–6 and 24 months post-OHCA, respectively 74 and 73% had a good PCPC score, defined as 1–2. Compared with normative data, OHCA children obtained worse sustained attention and processing speed scores 3–6 (n = 26) and 24 (n = 27) months post-OHCA. At 24 months, they also obtained worse intelligence, selective attention and cognitive flexibility scores. In children tested at both time-points (n = 19), no significant changes in neuropsychological outcomes were found over time. Intelligence scores did not correlate with PCPC. Conclusion: Although paediatric OHCA survivors had a good PCPC score 3–6 and 24 months post-OHCA, they obtained worse scores on important neuropsychological domains such as intelligence and executive functioning (attention and cognitive flexibility). Follow-up should continue over a longer life span in order to fully understand the long-term impact of OHCA in childhood.</p>

doi.org/10.1016/j.resuscitation.2021.07.043, hdl.handle.net/1765/136137
Journal of Clinical Medicine
Erasmus MC: University Medical Center Rotterdam

J.A. (Jeannette) Goudzwaard, SA (Sadhna) Chotkan, M.J.A.G. (Marjo) De Ronde - Tillmans, M.J. (Mattie) Lenzen, M.P.H. (Maarten) van Wiechen, J.F.W. (Joris) Ooms, … F.U.S. Mattace Raso. (2021). Multidimensional prognostic index and outcomes in older patients undergoing transcatheter aortic valve implantation. Journal of Clinical Medicine, 10(16). doi:10.3390/jcm10163529