<p>Background: Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensively studied. This study assessed the relationship between AG and UAG levels and body composition in patients with type 1 diabetes. Methods: We selected eighteen patients with type 1 diabetes and divided them into two groups: non-obese (BMI &lt; 25 kg/m<sup>2</sup>) and overweight (BMI ≥ 25 kg/m<sup>2</sup>). Demographics, parameters of body composition and serum parameters including AG and UAG, were assessed. Results: The patients with a BMI ≥ 25 kg/m<sup>2</sup> were older and had a longer duration of diabetes. AG and UAG levels were not significantly different between non-obese and overweight groups (mean AG non-obese ± SD: 44.5 ± 29.4 pg/ml and mean UAG non-obese 42.4 ± 20.7 pg/ml vs mean AG overweight ± SD: 46.1 ± 29.6 pg/ml and mean UAG overweight 47.2 ± 18.2 pg/ml). AG/UAG ratios did not discriminate between these groups. There was a positive association of insuline dose/kg bodyweight with BMI (r<sup>2</sup> = 0.45, p = 0.002). Conclusions: Surprisingly, unlike non-diabetics and in T2D, we did not observe a difference in plasma levels of AG and UAG between normal weight and overweight adult type 1 diabetics. However, we did observe a positive correlation between BMI and insuline dose/kg bodyweight, suggesting that exogenous insulin is more important than the ghrelin system in the development of obesity in type 1 diabetes.</p>

doi.org/10.1186/s13098-021-00699-4, hdl.handle.net/1765/136153
Diabetology and Metabolic Syndrome
Erasmus MC: University Medical Center Rotterdam

B. (Behiye) Ozcan, P.J.D. (Patric) Delhanty, T.M. (Martin) Huisman, J.A. (Jenny) Visser, S.J.C.M.M. Neggers, & AJ (Aart-Jan) van der Lely. (2021). Overweight and obesity in type 1 diabetes is not associated with higher ghrelin concentrations. Diabetology and Metabolic Syndrome, 13(1). doi:10.1186/s13098-021-00699-4