<p>High-frame-rate (HFR) echo-particle image velocimetry (echoPIV) is a promising tool for measuring intracardiac blood flow dynamics. In this study, we investigate the optimal ultrasound contrast agent (UCA: SonoVue) infusion rate and acoustic output to use for HFR echoPIV (PRF = 4900 Hz) in the left ventricle (LV) of patients. Three infusion rates (0.3, 0.6, and 1.2 ml/min) and five acoustic output amplitudes (by varying transmit voltage: 5, 10, 15, 20, and 30 V - corresponding to mechanical indices of 0.01, 0.02, 0.03, 0.04, and 0.06 at 60-mm depth) were tested in 20 patients admitted for symptoms of heart failure. We assess the accuracy of HFR echoPIV against pulsed-wave Doppler acquisitions obtained for mitral inflow and aortic outflow. In terms of image quality, the 1.2-ml/min infusion rate provided the highest contrast-to-background ratio (CBR) (3-dB improvement over 0.3 ml/min). The highest acoustic output tested resulted in the lowest CBR. Increased acoustic output also resulted in increased microbubble disruption. For the echoPIV results, the 1.2-ml/min infusion rate provided the best vector quality and accuracy; mid-range acoustic outputs (corresponding to 15-20-V transmit voltages) provided the best agreement with the pulsed-wave Doppler. Overall, the highest infusion rate (1.2 ml/min) and mid-range acoustic output amplitudes provided the best image quality and echoPIV results. </p>

doi.org/10.1109/TUFFC.2021.3066082, hdl.handle.net/1765/136173
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Erasmus MC: University Medical Center Rotterdam

J.D. (Jason) Voorneveld, L.B.H. (Lana) Keijzer, M. (Mihai) Strachinaru, D.J. (Daniel) Bowen, F.O. (Onur) Mutluer, A.F.W. (Ton) van der Steen, … J.G. (Hans) Bosch. (2021). Optimization of Microbubble Concentration and Acoustic Pressure for Left Ventricular High-Frame-Rate EchoPIV in Patients. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 68(7), 2432–2443. doi:10.1109/TUFFC.2021.3066082